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The overhead mark

Fixate is a mechanic that causes the mob to ignore its threat list and chase a specific player for a limited time.

Mobs introduced in Mists of Pandaria mark their current fixate target with an overhead mark resembling a pair of eyes.

The fixated player is supposed to run away and kite the mob around. Some fixate debuffs on players also give them a speed boost (Raigonn is an example).

Example mobs with fixate mechanics

The Pursuit ability of the  Krick and Ick encounter is effectively a fixate effect, but it is not named such, and uses a different icon to highlight the fixated player.