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A sanctum is a structure in the Warcraft universe. There are numerous locations named such:
- The Sanctum, the church in the ruined city of Stromgarde.
- The Sanctum, warlock guild in Silvermoon City.
- Arcane sanctums, a building type in Warcraft III.
- The Obsidian Sanctum
- The Sanctum of the Sages
- Covenant Sanctums, the places of the four Covenants in Shadowlands.