Sharptooth was the wolf companion of the Frostwolf clan chieftain Durotan on Azeroth. Sharptooth accompanied Durotan on his trip to warn Orgrim Doomhammer of the threat from Gul'dan and his Shadow Council. Sharptooth was killed by the same group of assassins who murdered both Durotan and Draka, and left their newborn child helpless in the forest.
In an alternate universe, the main-universe Thrall accompanied the Frostwolves and witnessed their murder. When one of the assassins killed Sharptooth, he turned to and killed Grukar who had initially summoned them.